May is ALS Awareness Month

May is ALS Awareness Month - Southeast Michigan Home Care Blog Posts | CareOne Senior Care - Picture1

CareOne Senior Care, knows, first hand, the challenges of living with and caring for a loved one that has been diagnosed with ALS.  Our personal experience as a family in finding and providing exceptional care to our loving Mother, who courageously fought ALS for six years,  inspired us to open CareOne Senior Care!  Our family owned and operated company is committed to providing care to you or your loved one at the same level of care that we expect for our family.    This is a personal journey for us and it’s an honor to have our clients as part of our CareOne Family.    In honor of our loved one, we strive to spread awareness of the ALS disease, the progress that is being made to understand and fight the disease and how we all can help.  The below article is credited to the ALS Association.

New Research Brings Help, Hope to People With ALS

ALS is a devastating disease with no cure. But researchers are working to change that. The increased awareness and donations provided by events like the ALS Ice Bucket Challenge—and by people like you—are making a real difference in the pace of discoveries, bringing us ever closer to the end of ALS.

Here are just a few examples of recent advancements in ALS research and technology:

Developing Biomarkers to Improve ALS Diagnosis

Diagnosing ALS can be difficult. There are no clear-cut tests to determine if someone has the disease, and the progression of the symptoms can look very different from one person to the next. Right now diagnosis takes about one year. We can do better!

Multiple efforts are ongoing to identify biomarkers, which are a substance in your body that can be tracked over time, like changes in blood, urine or cerebral spinal fluid (the fluid that surrounds and protects the brain and spinal cord). Biomarkers will not only help improve diagnosis times, but also help track disease progression and whether a drug hits its intended target in the body, all leading to more efficient clinical trials.

Exciting ongoing biomarker studies are underway, all racing to be the first ALS biomarker on the market. For example, changes in proteins found elevated in patient blood and cerebral spinal fluid, called neurofilament heavy chain, are close to release in the U.S. as a diagnostic ALS biomarker. A new biomarker that specifically detects a protein made by the C9orf72 expansion, the most common inherited ALS mutation, is under critical testing to complement an upcoming clinical trial targeting the C9orf72 mutation. Imaging biomarkers design to detect neuro-inflammation in the brain of people with ALS using combined brain imaging scans are being developed and optimized. All of these biomarker efforts and more are rapidly moving forward.

Ice Bucket Challenge Leads to Gene Discoveries

Perhaps the biggest news of the past year in the field of ALS research was the discovery of a new ALS gene, called NEK1. It was identified by a massive international effort, Project MinE, headed by Drs. John Landers from Massachusetts Medical School and Jonathan Glass from Emory University in the U.S.

The study’s goal is to map the DNA profiles of over 15,000 people with ALS and 7,500 people who do not have the disease for comparison. Researchers found that people with ALS are more likely to have a mutation in the NEK1 gene, which ended up known as one of the largest most common genetic contributors of ALS. Funding from The Association is now supporting studies to take research to the next step – to understand how NEK1 causes disease.

Since the ALS Ice Bucket Challenge, four new ALS genes have been identified by large ongoing global “big data” projects such as Project MinE, Genomic Translation for ALS Care (GTAC), the New York Genome Center, Answer ALS and others – all working together and supported in some way by The ALS Association. Collaboration between these large initiatives are paramount!

Each new gene identified represents a promising new target for drug development. All the collaborative work from gene discovery to understanding disease pathways is bringing us ever closer toward finding treatments and a cure to end ALS. And it’s a direct result of donations from people like you through the Ice Bucket Challenge and other fundraising events.

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